50-63-5, Chloroquine diphosphate
Lub npe | Chloroquine Diphosphate |
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Synonym | Ntau Synonyms |
Kev piav qhia | Chloroquine (diphosphate) yog ib qho tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob uas siv dav los kho mob malaria thiab mob caj dab rheumatoid.Chloroquine yog ib qho inhibitor ntawm autophagy thiab hu xov tooj zoo li receptors (TLRs). |
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Related Catalog | |
Hom phiaj | Autophagy, TLRs[1][2][3] |
Hauv Vitro | Chloroquine (CHQ, 20 μM) inhibits IL-12p70 tso tawm thiab txo Th1-priming peev xwm ntawm activated human monocyte-derived Langerhans-zoo li hlwb (MoLC).Chloroquine (CHQ, 20 μM) txhim kho IL-1-induced IL-23 secretion hauv MoLC thiab tom qab ntawd nce IL-17A tso tawm los ntawm primed CD4+ T cells[1].Chloroquine (25 μM) suppresses MMP-9 mRNA qhia hauv normoxia thiab hypoxia hauv niam txiv MDA-MB-231 hlwb.Chloroquine muaj cell-, koob tshuaj- thiab hypoxia-dependent teebmeem ntawm MMP-2, MMP-9 thiab MMP-13 mRNA qhia[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine txo qis HuH7 cell proliferation hauv vitro[3]. |
Hauv Vivo | Chloroquine (80 mg / kg, ip) tsis tiv thaiv kev loj hlob ntawm triple-negative MDA-MB-231 hlwb nrog siab lossis qis TLR9 qhia qib hauv cov qauv nas orthotopic[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine cuam tshuam cov qog loj hlob hauv tus qauv nas xenograft.Kev txhim kho HCC hauv DEN / NMOR nas qauv kuj tseem cuam tshuam los ntawm chloroquine[3]. |
Cell Assay | Cov hlwb raug coj mus rau hauv 6-zoo daim hlau nrog ib txwm kab lis kev cai nruab nrab nyob rau hauv lub xub ntiag ntawm lub tsheb los yog 25 los yog 50 μM chloroquine, kom txog rau thaum nyob ze ntawm confluency, tom qab uas lawv tau yaug nrog sterile phosphate-buffered saline (PBS) thiab kab lis kev cai ntxiv rau lub sij hawm qhia. hauv cov kab lis kev cai uas tsis muaj ntshav qab zib.Nyob rau lub sijhawm xav tau, cov kab lis kev cai nruab nrab yog muab pov tseg thiab cov hlwb tau sai sai hauv lysis tsis thiab qhia meej los ntawm centrifugation.Tom qab boiling lub supernatants nyob rau hauv txo sodium dodecyl sulphate (SDS) qauv tsis, sib npaug ntawm cov protein (100 μg) yog loaded ib txoj kab thiab cov qauv yog electrophoresed rau hauv 10 los yog 4-20% gradient polyacrylamide SDS gels, ces pauv mus rau ib tug nitrocellulose. daim nyias nyias.Txhawm rau txheeb xyuas TLR9, cov blots yog incubated thaum hmo ntuj ntawm 4 ° C nrog anti-TLR9 cov tshuaj tiv thaiv, diluted 1:500 hauv Tris-buffered saline nrog 0.1% (v/v) Tween-20 (TBST).Kev thauj khoom sib npaug tau lees paub nrog polyclonal luav anti-actin.Kev tshawb nrhiav thib ob yog ua nrog horseradish peroxidase-txuas ntxiv cov tshuaj tiv thaiv kab mob.Cov kab mob protein tau pom los ntawm chemiluminescence siv cov khoom siv ECL. |
Tsiaj Admin | Tswj thiab TLR9 siRNA MDA-MB-231 hlwb (5 × 105 hlwb nyob rau hauv 100 μL) yog inoculated rau hauv mammary rog pads ntawm plaub-lub lis piam-laus, tsis muaj zog nas (athymic liab qab / nu Foxn1).Kev kho yog pib xya hnub tom qab cov qog cell inoculation.Cov nas raug kho txhua hnub nrog rau cov tshuaj intraperitoneal (ip) chloroquine (80 mg / kg) lossis tsheb (PBS).Cov tsiaj raug saib xyuas txhua hnub rau kev kuaj mob.Kev ntsuas qog tau ua ob zaug hauv ib lub lis piam thiab cov qog ntim yog xam raws li tus qauv V = (π / 6) (d1 × d2) 3/2, qhov twg d1 thiab d2 yog cov kab mob perpendicular.Cov qog raug tso cai kom loj hlob rau 22 hnub, thaum lub sijhawm cov nas raug txi thiab cov qog raug txiav rau qhov ntsuas zaum kawg.Thoob plaws hauv qhov kev sim, cov tsiaj tau khaws cia nyob rau hauv cov kab mob tsis muaj kab mob ib puag ncig (20-21 ° C, 30-60% txheeb ze av noo thiab lub voj voog 12-h teeb pom kev zoo).Cov nas yog pub nrog cov tsiaj me me thiab muab cov dej tsis muaj menyuam ad libitum. |
Cov ntaub ntawv |
Boiling Point | 460.6ºC ntawm 760 mmHg |
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Melting Point | 200 ° C (lub kaum hli ntuj) (lit.) |
Molecular Formula | C18H32ClN3O8P2 |
Molecular Luj | 515.862 ib |
Flash Point | 232.3°C dej |
Exact Mass | 515.135315 |
PSA | 203.000 Nws |
LogP | 3.02640 ib |
Kev cia khoom | Desiccate ntawm RT |
Dej Solubility | H2O: 50 mg/ml, ntshiab |
CHEMICAL IDENTIFICATION
HNUB NYOOG HAZARD DATATXOJ CAI TSHIAB DATA
MUTATION DATA
|
Cim | GHS 07 |
---|---|
Lus Cim | Ceeb toom |
Cov Lus Qhia Txog Hazard | H302 |
Cov Lus Qhia Ua Ntej | P301 + P312 + P330 |
Cov cuab yeej tiv thaiv tus kheej | plua plav daim npog qhov ncauj hom N95 (US); Eyeshields; hnab looj tes |
Hazard Codes | Xn: Ua phem; |
Risk kab lus | R22 |
Cov lus nyab xeeb | S22-S24/25 |
RIDADR | 1544 ib |
WGK Germany | 3 |
RTECS | VB2450000 |
Ntim Group | III |
Hazard Class | 6.1 (b) |
HS Code | 293349090 ib |
Precursor 0 | |
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DownStream 1 | |
HS Code | 293349090 ib |
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Cov ntsiab lus | 2933499090. Lwm cov tshuaj uas muaj nyob rau hauv cov qauv quinoline los yog isoquinoline nplhaib-system (txawm los yog tsis hydrogenated), tsis ntxiv fused.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0% |
Itraconazole inhibits kev loj hlob ntawm glioblastoma los ntawm induction ntawm autophagy: kev koom tes ntawm txawv txav cov roj cholesterol. Autophagy 10(7), 1241-55, (2014) Glioblastoma yog ib qho mob hnyav tshaj plaws ntawm tib neeg cov qog nqaij hlav nrog cov tsos mob tsis zoo, thiab yog li ntawd qhov kev xav tau tseem ceeb muaj rau cov tswv yim kho tshiab rau kev tswj cov neeg mob glioblastoma.Itraconazol… | |
Regulators ntawm autophagosome tsim hauv Drosophila cov leeg. PLoS Genet.11(2), e1005006, (2015) Muab qhov sib txawv ntawm autophagy lub hom phiaj thiab kev tswj hwm, nws yog ib qho tseem ceeb rau kev ua tus cwj pwm autophagy hauv ntau hom cell thiab tej yam kev mob.Peb tau siv lub hauv paus myocyte cell kab lis kev cai los soj ntsuam lub luag haujlwm… | |
Ib txoj hauv kev sib xyaw ua ke los coj kev txhim kho cov hlau-chelateing inhibitors ntawm tus kab mob khaub thuas PA endonuclease. Mol.Pharmacol.87(2), 323-37, (2015) Tus kab mob npaws npaws PA endonuclease, uas cleaves capped cellular pre-mRNAs rau prime viral mRNA synthesis, yog lub hom phiaj zoo rau kev kho mob khaub thuas tshiab.Lub catalytic center ntawm t… |
TIAB SA 00069852 |
Acid phosphorique - N-(7-chloroquinoléin-4-yl)-N, N-diéthylpentane-1,4-diamine (2: 1) |
Chloroquine phosphate |
7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate |
EINECS 200-055-2 |
N-(7-chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine bis (phosphate) |
N4-(7-chloroquinolin-4-yl)-N1, N1-diethylpentane-1,4-diamine phosphate (1:2) |
N-(7-Chloro-4-quinolinyl)-N, N-diethyl-1,4-pentanediamine phosphate (1:2) |
N4-(7-Chloro-4-quinolyl)-N1, N1-diethyl-1,4-pentanediamine Diphosphate |
Chloroquine diphosphate ntsev |
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2) |
Aralen phosphate |
1,4-Pentanediamine, N-(7-chloro-4-quinolinyl)-N, N-diethyl-, phosphate (1:2) |
1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-N1, N1-diethyl-, phosphate (1:2) |
N-(7-Chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine phosphate (1:2) |
Chloroquine diphosphate |
Imagon |
Tresochin |
Chloroquinediphosphate |
Malaquin |
Phosphorosäure-N-(7-chlorchinolin-4-yl)-N, N-diethylpentan-1,4-diamin (2: 1) |
Lub npe | Chloroquine Diphosphate |
---|---|
Synonym | Ntau Synonyms |
Kev piav qhia | Chloroquine (diphosphate) yog ib qho tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob uas siv dav los kho mob malaria thiab mob caj dab rheumatoid.Chloroquine yog ib qho inhibitor ntawm autophagy thiab hu xov tooj zoo li receptors (TLRs). |
---|---|
Related Catalog | |
Hom phiaj | Autophagy, TLRs[1][2][3] |
Hauv Vitro | Chloroquine (CHQ, 20 μM) inhibits IL-12p70 tso tawm thiab txo Th1-priming peev xwm ntawm activated human monocyte-derived Langerhans-zoo li hlwb (MoLC).Chloroquine (CHQ, 20 μM) txhim kho IL-1-induced IL-23 secretion hauv MoLC thiab tom qab ntawd nce IL-17A tso tawm los ntawm primed CD4+ T cells[1].Chloroquine (25 μM) suppresses MMP-9 mRNA qhia hauv normoxia thiab hypoxia hauv niam txiv MDA-MB-231 hlwb.Chloroquine muaj cell-, koob tshuaj- thiab hypoxia-dependent teebmeem ntawm MMP-2, MMP-9 thiab MMP-13 mRNA qhia[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine txo qis HuH7 cell proliferation hauv vitro[3]. |
Hauv Vivo | Chloroquine (80 mg / kg, ip) tsis tiv thaiv kev loj hlob ntawm triple-negative MDA-MB-231 hlwb nrog siab lossis qis TLR9 qhia qib hauv cov qauv nas orthotopic[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine cuam tshuam cov qog loj hlob hauv tus qauv nas xenograft.Kev txhim kho HCC hauv DEN / NMOR nas qauv kuj tseem cuam tshuam los ntawm chloroquine[3]. |
Cell Assay | Cov hlwb raug coj mus rau hauv 6-zoo daim hlau nrog ib txwm kab lis kev cai nruab nrab nyob rau hauv lub xub ntiag ntawm lub tsheb los yog 25 los yog 50 μM chloroquine, kom txog rau thaum nyob ze ntawm confluency, tom qab uas lawv tau yaug nrog sterile phosphate-buffered saline (PBS) thiab kab lis kev cai ntxiv rau lub sij hawm qhia. hauv cov kab lis kev cai uas tsis muaj ntshav qab zib.Nyob rau lub sijhawm xav tau, cov kab lis kev cai nruab nrab yog muab pov tseg thiab cov hlwb tau sai sai hauv lysis tsis thiab qhia meej los ntawm centrifugation.Tom qab boiling lub supernatants nyob rau hauv txo sodium dodecyl sulphate (SDS) qauv tsis, sib npaug ntawm cov protein (100 μg) yog loaded ib txoj kab thiab cov qauv yog electrophoresed rau hauv 10 los yog 4-20% gradient polyacrylamide SDS gels, ces pauv mus rau ib tug nitrocellulose. daim nyias nyias.Txhawm rau txheeb xyuas TLR9, cov blots yog incubated thaum hmo ntuj ntawm 4 ° C nrog anti-TLR9 cov tshuaj tiv thaiv, diluted 1:500 hauv Tris-buffered saline nrog 0.1% (v/v) Tween-20 (TBST).Kev thauj khoom sib npaug tau lees paub nrog polyclonal luav anti-actin.Kev tshawb nrhiav thib ob yog ua nrog horseradish peroxidase-txuas ntxiv cov tshuaj tiv thaiv kab mob.Cov kab mob protein tau pom los ntawm chemiluminescence siv cov khoom siv ECL. |
Tsiaj Admin | Tswj thiab TLR9 siRNA MDA-MB-231 hlwb (5 × 105 hlwb nyob rau hauv 100 μL) yog inoculated rau hauv mammary rog pads ntawm plaub-lub lis piam-laus, tsis muaj zog nas (athymic liab qab / nu Foxn1).Kev kho yog pib xya hnub tom qab cov qog cell inoculation.Cov nas raug kho txhua hnub nrog rau cov tshuaj intraperitoneal (ip) chloroquine (80 mg / kg) lossis tsheb (PBS).Cov tsiaj raug saib xyuas txhua hnub rau kev kuaj mob.Kev ntsuas qog tau ua ob zaug hauv ib lub lis piam thiab cov qog ntim yog xam raws li tus qauv V = (π / 6) (d1 × d2) 3/2, qhov twg d1 thiab d2 yog cov kab mob perpendicular.Cov qog raug tso cai kom loj hlob rau 22 hnub, thaum lub sijhawm cov nas raug txi thiab cov qog raug txiav rau qhov ntsuas zaum kawg.Thoob plaws hauv qhov kev sim, cov tsiaj tau khaws cia nyob rau hauv cov kab mob tsis muaj kab mob ib puag ncig (20-21 ° C, 30-60% txheeb ze av noo thiab lub voj voog 12-h teeb pom kev zoo).Cov nas yog pub nrog cov tsiaj me me thiab muab cov dej tsis muaj menyuam ad libitum. |
Cov ntaub ntawv |
Boiling Point | 460.6ºC ntawm 760 mmHg |
---|---|
Melting Point | 200 ° C (lub kaum hli ntuj) (lit.) |
Molecular Formula | C18H32ClN3O8P2 |
Molecular Luj | 515.862 ib |
Flash Point | 232.3°C dej |
Exact Mass | 515.135315 |
PSA | 203.000 Nws |
LogP | 3.02640 ib |
Kev cia khoom | Desiccate ntawm RT |
Dej Solubility | H2O: 50 mg/ml, ntshiab |
CHEMICAL IDENTIFICATION
HNUB NYOOG HAZARD DATATXOJ CAI TSHIAB DATA
MUTATION DATA
|
Cim | GHS 07 |
---|---|
Lus Cim | Ceeb toom |
Cov Lus Qhia Txog Hazard | H302 |
Cov Lus Qhia Ua Ntej | P301 + P312 + P330 |
Cov cuab yeej tiv thaiv tus kheej | plua plav daim npog qhov ncauj hom N95 (US); Eyeshields; hnab looj tes |
Hazard Codes | Xn: Ua phem; |
Risk kab lus | R22 |
Cov lus nyab xeeb | S22-S24/25 |
RIDADR | 1544 ib |
WGK Germany | 3 |
RTECS | VB2450000 |
Ntim Group | III |
Hazard Class | 6.1 (b) |
HS Code | 293349090 ib |
Precursor 0 | |
---|---|
DownStream 1 | |
HS Code | 293349090 ib |
---|---|
Cov ntsiab lus | 2933499090. Lwm cov tshuaj uas muaj nyob rau hauv cov qauv quinoline los yog isoquinoline nplhaib-system (txawm los yog tsis hydrogenated), tsis ntxiv fused.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0% |
Itraconazole inhibits kev loj hlob ntawm glioblastoma los ntawm induction ntawm autophagy: kev koom tes ntawm txawv txav cov roj cholesterol. Autophagy 10(7), 1241-55, (2014) Glioblastoma yog ib qho mob hnyav tshaj plaws ntawm tib neeg cov qog nqaij hlav nrog cov tsos mob tsis zoo, thiab yog li ntawd qhov kev xav tau tseem ceeb muaj rau cov tswv yim kho tshiab rau kev tswj cov neeg mob glioblastoma.Itraconazol… | |
Regulators ntawm autophagosome tsim hauv Drosophila cov leeg. PLoS Genet.11(2), e1005006, (2015) Muab qhov sib txawv ntawm autophagy lub hom phiaj thiab kev tswj hwm, nws yog ib qho tseem ceeb rau kev ua tus cwj pwm autophagy hauv ntau hom cell thiab tej yam kev mob.Peb tau siv lub hauv paus myocyte cell kab lis kev cai los soj ntsuam lub luag haujlwm… | |
Ib txoj hauv kev sib xyaw ua ke los coj kev txhim kho cov hlau-chelateing inhibitors ntawm tus kab mob khaub thuas PA endonuclease. Mol.Pharmacol.87(2), 323-37, (2015) Tus kab mob npaws npaws PA endonuclease, uas cleaves capped cellular pre-mRNAs rau prime viral mRNA synthesis, yog lub hom phiaj zoo rau kev kho mob khaub thuas tshiab.Lub catalytic center ntawm t… |
TIAB SA 00069852 |
Acid phosphorique - N-(7-chloroquinoléin-4-yl)-N, N-diéthylpentane-1,4-diamine (2: 1) |
Chloroquine phosphate |
7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate |
EINECS 200-055-2 |
N-(7-chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine bis (phosphate) |
N4-(7-chloroquinolin-4-yl)-N1, N1-diethylpentane-1,4-diamine phosphate (1:2) |
N-(7-Chloro-4-quinolinyl)-N, N-diethyl-1,4-pentanediamine phosphate (1:2) |
N4-(7-Chloro-4-quinolyl)-N1, N1-diethyl-1,4-pentanediamine Diphosphate |
Chloroquine diphosphate ntsev |
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2) |
Aralen phosphate |
1,4-Pentanediamine, N-(7-chloro-4-quinolinyl)-N, N-diethyl-, phosphate (1:2) |
1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-N1, N1-diethyl-, phosphate (1:2) |
N-(7-Chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine phosphate (1:2) |
Chloroquine diphosphate |
Imagon |
Tresochin |
Chloroquinediphosphate |
Malaquin |
Phosphorosäure-N-(7-chlorchinolin-4-yl)-N, N-diethylpentan-1,4-diamin (2: 1) |
tiv tauj peb:
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Ntim
Vim li cas thiaj xaiv US?
1. Xaiv cov khoom raw nruj me ntsis, peb cov khoom yog qhov siab tshaj plaws purity.
2. Tus nqi tsim nyog thiab kev sib tw.Muab cov kev pabcuam zoo tshaj plaws thiab kev tshaj lij.
3.Kev xa khoom sai ntawm cov qauv, cov qauv los ntawm Tshuag.Txhim khu kev xa khoom.
4.Txhua qhov kev paub dhau los ntawm ntau lub thawv ntim khoom hauv Suav hiav txwv chaw nres nkoj.
5. Qhov zoo tshaj plaws tom qab kev pab cuam tom qab xa khoom.
6. Cov ntaub ntawv tshaj lij rau koj cov kev cai tshem tawm.
1.Peb tuaj yeem lav qhov zoo?
Ib txwm ua qauv ua ntej ua ntej ntau lawm;Ib txwm soj ntsuam zaum kawg ua ntej ua zaub mov xa tuaj.
2.Vim li cas koj yuav tsum yuav los ntawm peb?
(1) High purity zoo zoo nrog cov nqi sib tw zoo nkauj.(2) Lub peev xwm loj ntawm cov khoom lag luam ruaj khov.(3) Kev nyab xeeb thiab ceev khoom xa tuaj los ntawm hiav txwv / los ntawm huab cua.(4) Cov qauv txiav txim tau txais. (5) Zoo thiab nruj packing raws li customized.
3.Koj tus MOQ yog dab tsi?Lub sijhawm xa khoom yog dab tsi?
Feem ntau, peb cov MOQ yog 1kg.Tab sis nws tuaj yeem yog raws li koj qhov kev thov tiag tiag.Txhua qhov ntau yog OK.
Feem ntau 2-3 hnub tom qab tau txais cov nyiaj them poob haujlwm (tshwj tsis yog suav hnub so)
4.Puas muaj luv nqi?
Tau kawg, peb yuav txiav txim siab luv nqi rau cov neeg yuav khoom thawj zaug, txawm tias muaj ntau ntau.
5.Dab tsi cov nqe lus them nqi koj txais?peb xav lees txais kev hloov nyiaj hauv tuam txhab, Western Union lossis BTC.