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50-63-5, Chloroquine diphosphate

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Khoom cim npe

Cov npe

Lub npe Chloroquine Diphosphate
Synonym Ntau Synonyms

 Chloroquine diphosphate Biological Activity

Kev piav qhia Chloroquine (diphosphate) yog ib qho tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob uas siv dav los kho mob malaria thiab mob caj dab rheumatoid.Chloroquine yog ib qho inhibitor ntawm autophagy thiab hu xov tooj zoo li receptors (TLRs).
Related Catalog
Hom phiaj

Autophagy, TLRs[1][2][3]

Hauv Vitro Chloroquine (CHQ, 20 μM) inhibits IL-12p70 tso tawm thiab txo Th1-priming peev xwm ntawm activated human monocyte-derived Langerhans-zoo li hlwb (MoLC).Chloroquine (CHQ, 20 μM) txhim kho IL-1-induced IL-23 secretion hauv MoLC thiab tom qab ntawd nce IL-17A tso tawm los ntawm primed CD4+ T cells[1].Chloroquine (25 μM) suppresses MMP-9 mRNA qhia hauv normoxia thiab hypoxia hauv niam txiv MDA-MB-231 hlwb.Chloroquine muaj cell-, koob tshuaj- thiab hypoxia-dependent teebmeem ntawm MMP-2, MMP-9 thiab MMP-13 mRNA qhia[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine txo qis HuH7 cell proliferation hauv vitro[3].
Hauv Vivo Chloroquine (80 mg / kg, ip) tsis tiv thaiv kev loj hlob ntawm triple-negative MDA-MB-231 hlwb nrog siab lossis qis TLR9 qhia qib hauv cov qauv nas orthotopic[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine cuam tshuam cov qog loj hlob hauv tus qauv nas xenograft.Kev txhim kho HCC hauv DEN / NMOR nas qauv kuj tseem cuam tshuam los ntawm chloroquine[3].
Cell Assay Cov hlwb raug coj mus rau hauv 6-zoo daim hlau nrog ib txwm kab lis kev cai nruab nrab nyob rau hauv lub xub ntiag ntawm lub tsheb los yog 25 los yog 50 μM chloroquine, kom txog rau thaum nyob ze ntawm confluency, tom qab uas lawv tau yaug nrog sterile phosphate-buffered saline (PBS) thiab kab lis kev cai ntxiv rau lub sij hawm qhia. hauv cov kab lis kev cai uas tsis muaj ntshav qab zib.Nyob rau lub sijhawm xav tau, cov kab lis kev cai nruab nrab yog muab pov tseg thiab cov hlwb tau sai sai hauv lysis tsis thiab qhia meej los ntawm centrifugation.Tom qab boiling lub supernatants nyob rau hauv txo sodium dodecyl sulphate (SDS) qauv tsis, sib npaug ntawm cov protein (100 μg) yog loaded ib txoj kab thiab cov qauv yog electrophoresed rau hauv 10 los yog 4-20% gradient polyacrylamide SDS gels, ces pauv mus rau ib tug nitrocellulose. daim nyias nyias.Txhawm rau txheeb xyuas TLR9, cov blots yog incubated thaum hmo ntuj ntawm 4 ° C nrog anti-TLR9 cov tshuaj tiv thaiv, diluted 1:500 hauv Tris-buffered saline nrog 0.1% (v/v) Tween-20 (TBST).Kev thauj khoom sib npaug tau lees paub nrog polyclonal luav anti-actin.Kev tshawb nrhiav thib ob yog ua nrog horseradish peroxidase-txuas ntxiv cov tshuaj tiv thaiv kab mob.Cov kab mob protein tau pom los ntawm chemiluminescence siv cov khoom siv ECL.
Tsiaj Admin Tswj thiab TLR9 siRNA MDA-MB-231 hlwb (5 × 105 hlwb nyob rau hauv 100 μL) yog inoculated rau hauv mammary rog pads ntawm plaub-lub lis piam-laus, tsis muaj zog nas (athymic liab qab / nu Foxn1).Kev kho yog pib xya hnub tom qab cov qog cell inoculation.Cov nas raug kho txhua hnub nrog rau cov tshuaj intraperitoneal (ip) chloroquine (80 mg / kg) lossis tsheb (PBS).Cov tsiaj raug saib xyuas txhua hnub rau kev kuaj mob.Kev ntsuas qog tau ua ob zaug hauv ib lub lis piam thiab cov qog ntim yog xam raws li tus qauv V = (π / 6) (d1 × d2) 3/2, qhov twg d1 thiab d2 yog cov kab mob perpendicular.Cov qog raug tso cai kom loj hlob rau 22 hnub, thaum lub sijhawm cov nas raug txi thiab cov qog raug txiav rau qhov ntsuas zaum kawg.Thoob plaws hauv qhov kev sim, cov tsiaj tau khaws cia nyob rau hauv cov kab mob tsis muaj kab mob ib puag ncig (20-21 ° C, 30-60% txheeb ze av noo thiab lub voj voog 12-h teeb pom kev zoo).Cov nas yog pub nrog cov tsiaj me me thiab muab cov dej tsis muaj menyuam ad libitum.
Cov ntaub ntawv

[1]. Hais A, et al.Chloroquine txhawb nqa IL-17 ntau lawm los ntawm CD4 + T hlwb ntawm p38-dependent IL-23 tso tawm los ntawm monocyte-derived Langerhans-zoo li hlwb.J Immunol.2014 Kaum Ob Hlis 15; 193(12): 6135-43.

[2]. Tuomela J, et al.Chloroquine muaj cov qog-inhibitory thiab qog-txhawb cov teebmeem hauv triple-negative cancer mis.Oncol Lett.2013 Dec; 6(6): 1665-1672.

[3]. Mohamed FE, et al.Cov nyhuv ntawm tus xov tooj zoo li tus neeg txais xov tooj 7 thiab 9 lub hom phiaj kho kom tiv thaiv kev loj hlob ntawm hepatocellular carcinoma.Lub siab Int.2014 Jul 2. doi: 10.1111/liv.12626.

 Chemical & Physical Properties

Boiling Point 460.6ºC ntawm 760 mmHg
Melting Point 200 ° C (lub kaum hli ntuj) (lit.)
Molecular Formula C18H32ClN3O8P2
Molecular Luj 515.862 ib
Flash Point 232.3°C dej
Exact Mass 515.135315
PSA 203.000 Nws
LogP 3.02640 ib
Kev cia khoom Desiccate ntawm RT
Dej Solubility H2O: 50 mg/ml, ntshiab

 Cov ntaub ntawv toxicological

CHEMICAL IDENTIFICATION

RTECS NUMBER:
VB2450000
CHEMICAL NAME:
Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
CAS Nr .:
50-63-5 : kuv
LAST UPDATED:
199606 ib
DAIM NTAWV CEEB TOOM:
30
MOLECULAR FORMULA:
C18-H26-Cl-N3.2H3-O4-P
MOLECULAR WEIGHT:
515.92 ib
WISWESSER LINE NOTATION:
T66 BNJ EMY1&3N2&2 IG &P2-O6

HNUB NYOOG HAZARD DATA

TXOJ CAI TSHIAB DATA

TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
8 571 kwg
TOXIC EFFECTS:
Gastrointestinal - xeev siab los yog ntuav Gastrointestinal - lwm yam kev hloov
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
8 571 kwg
TOXIC EFFECTS:
Gastrointestinal - ulceration los yog los ntshav los ntawm duodenum Gastrointestinal - xeev siab los yog ntuav Gastrointestinal - lwm yam kev hloov
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - me nyuam
DOSE/DURATION:
250 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - coma
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - poj niam
DOSE/DURATION:
167 mg/kg
TOXIC EFFECTS:
Cardiac - EKG hloov pauv tsis kuaj pom qhov cuam tshuam ntawm Vascular - BP txo qis tsis muaj tus cwj pwm hauv autonomic seem ntsws, thorax, lossis ua pa - ua pa nyuaj siab
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
179 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
600 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
500 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Intraperitoneal
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
68 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - convulsions los yog cuam tshuam rau kev qaug dab peg
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Subcutaneous
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
200 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Txhaj tshuaj
SPECIES tau saib:
Mammal - dog
DOSE/DURATION:
8 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - somnolence (kev nyuaj siab dav dav)
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Txhaj tshuaj
SPECIES tau saib:
noog - domestic
DOSE/DURATION:
64500 ug/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
8820 mg/kg/21W-C
TOXIC EFFECTS:
Mob plawv - lwm yam kev hloov siab - kab mob siab (hepatocellular necrosis), diffuse ntsig txog cov ntaub ntawv mob - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Intraperitoneal
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
840 mg/kg/21D-I
TOXIC EFFECTS:
Cwj Pwm - noj zaub mov (tsiaj) raum, Ureter, zais zis - tso zis ntim txo Nutritional thiab tag nrho metabolic - poob phaus los yog poob phaus
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Subcutaneous
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
400 mg/kg/10D-I
TOXIC EFFECTS:
Lub raum, Ureter, zais zis - proteinuria raum, Ureter, zais zis - lwm yam kev hloov hauv cov zis muaj pes tsawg leeg Biochemical - Enzyme inhibition, induction, lossis hloov ntshav lossis cov ntaub so ntswg - phosphatase
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Ocular
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
72 ug/kg/12D-I
TOXIC EFFECTS:
Sense Organs and Special Senses (Qhov Muag) – corneal puas
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Mammal - dog
DOSE/DURATION:
280 mg/kg/14D-I
TOXIC EFFECTS:
Kev coj cwj pwm - tshee hnyo ntsig txog cov ntaub ntawv Chronic - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Primate - liab
DOSE/DURATION:
1 gm/kg/10D-I
TOXIC EFFECTS:
Lub siab - fatty siab degeneration Khoom noj khoom haus thiab tag nrho metabolic - poob los yog txo qhov hnyav nce ntsig txog cov ntaub ntawv Chronic - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
1200 mg/kg
SEX/DURATION:
poj niam 5-16 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau Embryo lossis Fetus - fetotoxicity (tshwj tsis yog tuag, piv txwv li, stunted fetus)
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
550 mg/kg
SEX/DURATION:
poj niam 9 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - Kev loj hlob tshwj xeeb - qhov muag / pob ntseg
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
750 mg/kg
SEX/DURATION:
poj niam 9 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau Embryo lossis Fetus - fetal tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Intraperitoneal
DOSE:
80 mg/kg
SEX/DURATION:
poj niam 20-21 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - Cov kev loj hlob tshwj xeeb - kev ua pa ua pa Reproductive - cuam tshuam rau cov me nyuam mos - lub cev
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Subcutaneous
DOSE:
475 mg/kg
SEX/DURATION:
poj niam 10-14 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau cov me nyuam mos - lub cev

MUTATION DATA

TSEEM CEEB:
Sister chromatid pauv
TEST SYSTEM:
Nroj tsuag - hamster Lung
DOSE/DURATION:
100 ug/l
CEEB TOOM:
CBTOE2 Cell Biology thiab Toxicology.(Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986 *** REVIEWS *** TOXICOLOGY REVIEW INTEAG Internist.(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(tseem ceeb)/page/xyoo: 15,7,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X4486 No. of Facilities: 40 (kwv yees) No. of Industries: 2 No. of Occupations: 3 No. 644 (kwv yees) No. Ntawm Cov Poj Niam Ua Haujlwm: 238 (kwv yees)

 Cov ntaub ntawv kev nyab xeeb

Cim GHS 07
GHS 07
Lus Cim Ceeb toom
Cov Lus Qhia Txog Hazard H302
Cov Lus Qhia Ua Ntej P301 + P312 + P330
Cov cuab yeej tiv thaiv tus kheej plua plav daim npog qhov ncauj hom N95 (US); Eyeshields; hnab looj tes
Hazard Codes Xn: Ua phem;
Risk kab lus R22
Cov lus nyab xeeb S22-S24/25
RIDADR 1544 ib
WGK Germany 3
RTECS VB2450000
Ntim Group III
Hazard Class 6.1 (b)
HS Code 293349090 ib

 Precursor & DownStream

Precursor 0
DownStream 1

 Kev lis kev cai

HS Code 293349090 ib
Cov ntsiab lus 2933499090. Lwm cov tshuaj uas muaj nyob rau hauv cov qauv quinoline los yog isoquinoline nplhaib-system (txawm los yog tsis hydrogenated), tsis ntxiv fused.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0%

 Cov ntawv108

Ntau cov ntawv

Itraconazole inhibits kev loj hlob ntawm glioblastoma los ntawm induction ntawm autophagy: kev koom tes ntawm txawv txav cov roj cholesterol.

Autophagy 10(7), 1241-55, (2014)

Glioblastoma yog ib qho mob hnyav tshaj plaws ntawm tib neeg cov qog nqaij hlav nrog cov tsos mob tsis zoo, thiab yog li ntawd qhov kev xav tau tseem ceeb muaj rau cov tswv yim kho tshiab rau kev tswj cov neeg mob glioblastoma.Itraconazol…

Regulators ntawm autophagosome tsim hauv Drosophila cov leeg.

PLoS Genet.11(2), e1005006, (2015)

Muab qhov sib txawv ntawm autophagy lub hom phiaj thiab kev tswj hwm, nws yog ib qho tseem ceeb rau kev ua tus cwj pwm autophagy hauv ntau hom cell thiab tej yam kev mob.Peb tau siv lub hauv paus myocyte cell kab lis kev cai los soj ntsuam lub luag haujlwm…

Ib txoj hauv kev sib xyaw ua ke los coj kev txhim kho cov hlau-chelateing inhibitors ntawm tus kab mob khaub thuas PA endonuclease.

Mol.Pharmacol.87(2), 323-37, (2015)

Tus kab mob npaws npaws PA endonuclease, uas cleaves capped cellular pre-mRNAs rau prime viral mRNA synthesis, yog lub hom phiaj zoo rau kev kho mob khaub thuas tshiab.Lub catalytic center ntawm t…

 Synonyms

TIAB SA 00069852
Acid phosphorique - N-(7-chloroquinoléin-4-yl)-N, N-diéthylpentane-1,4-diamine (2: 1)
Chloroquine phosphate
7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate
EINECS 200-055-2
N-(7-chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine bis (phosphate)
N4-(7-chloroquinolin-4-yl)-N1, N1-diethylpentane-1,4-diamine phosphate (1:2)
N-(7-Chloro-4-quinolinyl)-N, N-diethyl-1,4-pentanediamine phosphate (1:2)
N4-(7-Chloro-4-quinolyl)-N1, N1-diethyl-1,4-pentanediamine Diphosphate
Chloroquine diphosphate ntsev
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
Aralen phosphate
1,4-Pentanediamine, N-(7-chloro-4-quinolinyl)-N, N-diethyl-, phosphate (1:2)
1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-N1, N1-diethyl-, phosphate (1:2)
N-(7-Chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine phosphate (1:2)
Chloroquine diphosphate
Imagon
Tresochin
Chloroquinediphosphate
Malaquin
Phosphorosäure-N-(7-chlorchinolin-4-yl)-N, N-diethylpentan-1,4-diamin (2: 1)

 

Cov npe

Lub npe Chloroquine Diphosphate
Synonym Ntau Synonyms

 Chloroquine diphosphate Biological Activity

Kev piav qhia Chloroquine (diphosphate) yog ib qho tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob uas siv dav los kho mob malaria thiab mob caj dab rheumatoid.Chloroquine yog ib qho inhibitor ntawm autophagy thiab hu xov tooj zoo li receptors (TLRs).
Related Catalog
Hom phiaj

Autophagy, TLRs[1][2][3]

Hauv Vitro Chloroquine (CHQ, 20 μM) inhibits IL-12p70 tso tawm thiab txo Th1-priming peev xwm ntawm activated human monocyte-derived Langerhans-zoo li hlwb (MoLC).Chloroquine (CHQ, 20 μM) txhim kho IL-1-induced IL-23 secretion hauv MoLC thiab tom qab ntawd nce IL-17A tso tawm los ntawm primed CD4+ T cells[1].Chloroquine (25 μM) suppresses MMP-9 mRNA qhia hauv normoxia thiab hypoxia hauv niam txiv MDA-MB-231 hlwb.Chloroquine muaj cell-, koob tshuaj- thiab hypoxia-dependent teebmeem ntawm MMP-2, MMP-9 thiab MMP-13 mRNA qhia[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine txo qis HuH7 cell proliferation hauv vitro[3].
Hauv Vivo Chloroquine (80 mg / kg, ip) tsis tiv thaiv kev loj hlob ntawm triple-negative MDA-MB-231 hlwb nrog siab lossis qis TLR9 qhia qib hauv cov qauv nas orthotopic[2].TLR7 thiab TLR9 inhibition siv IRS-954 lossis chloroquine cuam tshuam cov qog loj hlob hauv tus qauv nas xenograft.Kev txhim kho HCC hauv DEN / NMOR nas qauv kuj tseem cuam tshuam los ntawm chloroquine[3].
Cell Assay Cov hlwb raug coj mus rau hauv 6-zoo daim hlau nrog ib txwm kab lis kev cai nruab nrab nyob rau hauv lub xub ntiag ntawm lub tsheb los yog 25 los yog 50 μM chloroquine, kom txog rau thaum nyob ze ntawm confluency, tom qab uas lawv tau yaug nrog sterile phosphate-buffered saline (PBS) thiab kab lis kev cai ntxiv rau lub sij hawm qhia. hauv cov kab lis kev cai uas tsis muaj ntshav qab zib.Nyob rau lub sijhawm xav tau, cov kab lis kev cai nruab nrab yog muab pov tseg thiab cov hlwb tau sai sai hauv lysis tsis thiab qhia meej los ntawm centrifugation.Tom qab boiling lub supernatants nyob rau hauv txo sodium dodecyl sulphate (SDS) qauv tsis, sib npaug ntawm cov protein (100 μg) yog loaded ib txoj kab thiab cov qauv yog electrophoresed rau hauv 10 los yog 4-20% gradient polyacrylamide SDS gels, ces pauv mus rau ib tug nitrocellulose. daim nyias nyias.Txhawm rau txheeb xyuas TLR9, cov blots yog incubated thaum hmo ntuj ntawm 4 ° C nrog anti-TLR9 cov tshuaj tiv thaiv, diluted 1:500 hauv Tris-buffered saline nrog 0.1% (v/v) Tween-20 (TBST).Kev thauj khoom sib npaug tau lees paub nrog polyclonal luav anti-actin.Kev tshawb nrhiav thib ob yog ua nrog horseradish peroxidase-txuas ntxiv cov tshuaj tiv thaiv kab mob.Cov kab mob protein tau pom los ntawm chemiluminescence siv cov khoom siv ECL.
Tsiaj Admin Tswj thiab TLR9 siRNA MDA-MB-231 hlwb (5 × 105 hlwb nyob rau hauv 100 μL) yog inoculated rau hauv mammary rog pads ntawm plaub-lub lis piam-laus, tsis muaj zog nas (athymic liab qab / nu Foxn1).Kev kho yog pib xya hnub tom qab cov qog cell inoculation.Cov nas raug kho txhua hnub nrog rau cov tshuaj intraperitoneal (ip) chloroquine (80 mg / kg) lossis tsheb (PBS).Cov tsiaj raug saib xyuas txhua hnub rau kev kuaj mob.Kev ntsuas qog tau ua ob zaug hauv ib lub lis piam thiab cov qog ntim yog xam raws li tus qauv V = (π / 6) (d1 × d2) 3/2, qhov twg d1 thiab d2 yog cov kab mob perpendicular.Cov qog raug tso cai kom loj hlob rau 22 hnub, thaum lub sijhawm cov nas raug txi thiab cov qog raug txiav rau qhov ntsuas zaum kawg.Thoob plaws hauv qhov kev sim, cov tsiaj tau khaws cia nyob rau hauv cov kab mob tsis muaj kab mob ib puag ncig (20-21 ° C, 30-60% txheeb ze av noo thiab lub voj voog 12-h teeb pom kev zoo).Cov nas yog pub nrog cov tsiaj me me thiab muab cov dej tsis muaj menyuam ad libitum.
Cov ntaub ntawv

[1]. Hais A, et al.Chloroquine txhawb nqa IL-17 ntau lawm los ntawm CD4 + T hlwb ntawm p38-dependent IL-23 tso tawm los ntawm monocyte-derived Langerhans-zoo li hlwb.J Immunol.2014 Kaum Ob Hlis 15; 193(12): 6135-43.

[2]. Tuomela J, et al.Chloroquine muaj cov qog-inhibitory thiab qog-txhawb cov teebmeem hauv triple-negative cancer mis.Oncol Lett.2013 Dec; 6(6): 1665-1672.

[3]. Mohamed FE, et al.Cov nyhuv ntawm tus xov tooj zoo li tus neeg txais xov tooj 7 thiab 9 lub hom phiaj kho kom tiv thaiv kev loj hlob ntawm hepatocellular carcinoma.Lub siab Int.2014 Jul 2. doi: 10.1111/liv.12626.

 Chemical & Physical Properties

Boiling Point 460.6ºC ntawm 760 mmHg
Melting Point 200 ° C (lub kaum hli ntuj) (lit.)
Molecular Formula C18H32ClN3O8P2
Molecular Luj 515.862 ib
Flash Point 232.3°C dej
Exact Mass 515.135315
PSA 203.000 Nws
LogP 3.02640 ib
Kev cia khoom Desiccate ntawm RT
Dej Solubility H2O: 50 mg/ml, ntshiab

 Cov ntaub ntawv toxicological

CHEMICAL IDENTIFICATION

RTECS NUMBER:
VB2450000
CHEMICAL NAME:
Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
CAS Nr .:
50-63-5 : kuv
LAST UPDATED:
199606 ib
DAIM NTAWV CEEB TOOM:
30
MOLECULAR FORMULA:
C18-H26-Cl-N3.2H3-O4-P
MOLECULAR WEIGHT:
515.92 ib
WISWESSER LINE NOTATION:
T66 BNJ EMY1&3N2&2 IG &P2-O6

HNUB NYOOG HAZARD DATA

TXOJ CAI TSHIAB DATA

TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
8 571 kwg
TOXIC EFFECTS:
Gastrointestinal - xeev siab los yog ntuav Gastrointestinal - lwm yam kev hloov
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
8 571 kwg
TOXIC EFFECTS:
Gastrointestinal - ulceration los yog los ntshav los ntawm duodenum Gastrointestinal - xeev siab los yog ntuav Gastrointestinal - lwm yam kev hloov
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - me nyuam
DOSE/DURATION:
250 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - coma
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - poj niam
DOSE/DURATION:
167 mg/kg
TOXIC EFFECTS:
Cardiac - EKG hloov pauv tsis kuaj pom qhov cuam tshuam ntawm Vascular - BP txo qis tsis muaj tus cwj pwm hauv autonomic seem ntsws, thorax, lossis ua pa - ua pa nyuaj siab
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Tib neeg - man
DOSE/DURATION:
179 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
600 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
500 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Intraperitoneal
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
68 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - convulsions los yog cuam tshuam rau kev qaug dab peg
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Subcutaneous
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
200 mg/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
LDLO - Tsawg tshaj tawm cov koob tshuaj tuag taus
ROUTE OF EXPOSURE:
Txhaj tshuaj
SPECIES tau saib:
Mammal - dog
DOSE/DURATION:
8 mg/kg
TOXIC EFFECTS:
Kev coj cwj pwm - somnolence (kev nyuaj siab dav dav)
TSEEM CEEB:
LD50 - koob tshuaj tuag, 50 feem pua ​​tua
ROUTE OF EXPOSURE:
Txhaj tshuaj
SPECIES tau saib:
noog - domestic
DOSE/DURATION:
64500 ug/kg
TOXIC EFFECTS:
Cov ntsiab lus ntawm cov tshuaj lom tsis tau tshaj tawm lwm yam tshaj li tus nqi noj tshuaj tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
8820 mg/kg/21W-C
TOXIC EFFECTS:
Mob plawv - lwm yam kev hloov siab - kab mob siab (hepatocellular necrosis), diffuse ntsig txog cov ntaub ntawv mob - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Intraperitoneal
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
840 mg/kg/21D-I
TOXIC EFFECTS:
Cwj Pwm - noj zaub mov (tsiaj) raum, Ureter, zais zis - tso zis ntim txo Nutritional thiab tag nrho metabolic - poob phaus los yog poob phaus
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Subcutaneous
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
400 mg/kg/10D-I
TOXIC EFFECTS:
Lub raum, Ureter, zais zis - proteinuria raum, Ureter, zais zis - lwm yam kev hloov hauv cov zis muaj pes tsawg leeg Biochemical - Enzyme inhibition, induction, lossis hloov ntshav lossis cov ntaub so ntswg - phosphatase
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Ocular
SPECIES tau saib:
Rodent - nas
DOSE/DURATION:
72 ug/kg/12D-I
TOXIC EFFECTS:
Sense Organs and Special Senses (Qhov Muag) – corneal puas
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Mammal - dog
DOSE/DURATION:
280 mg/kg/14D-I
TOXIC EFFECTS:
Kev coj cwj pwm - tshee hnyo ntsig txog cov ntaub ntawv Chronic - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
SPECIES tau saib:
Primate - liab
DOSE/DURATION:
1 gm/kg/10D-I
TOXIC EFFECTS:
Lub siab - fatty siab degeneration Khoom noj khoom haus thiab tag nrho metabolic - poob los yog txo qhov hnyav nce ntsig txog cov ntaub ntawv Chronic - tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
1200 mg/kg
SEX/DURATION:
poj niam 5-16 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau Embryo lossis Fetus - fetotoxicity (tshwj tsis yog tuag, piv txwv li, stunted fetus)
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
550 mg/kg
SEX/DURATION:
poj niam 9 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - Kev loj hlob tshwj xeeb - qhov muag / pob ntseg
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Qhov ncauj
DOSE:
750 mg/kg
SEX/DURATION:
poj niam 9 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau Embryo lossis Fetus - fetal tuag
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Intraperitoneal
DOSE:
80 mg/kg
SEX/DURATION:
poj niam 20-21 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - Cov kev loj hlob tshwj xeeb - kev ua pa ua pa Reproductive - cuam tshuam rau cov me nyuam mos - lub cev
TSEEM CEEB:
TDLO - Tsawg tshaj tawm cov tshuaj toxicity
ROUTE OF EXPOSURE:
Subcutaneous
DOSE:
475 mg/kg
SEX/DURATION:
poj niam 10-14 hnub tom qab xeeb tub
TOXIC EFFECTS:
Kev yug me nyuam - cuam tshuam rau cov me nyuam mos - lub cev

MUTATION DATA

TSEEM CEEB:
Sister chromatid pauv
TEST SYSTEM:
Nroj tsuag - hamster Lung
DOSE/DURATION:
100 ug/l
CEEB TOOM:
CBTOE2 Cell Biology thiab Toxicology.(Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986 *** REVIEWS *** TOXICOLOGY REVIEW INTEAG Internist.(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(tseem ceeb)/page/xyoo: 15,7,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X4486 No. of Facilities: 40 (kwv yees) No. of Industries: 2 No. of Occupations: 3 No. 644 (kwv yees) No. Ntawm Cov Poj Niam Ua Haujlwm: 238 (kwv yees)

 Cov ntaub ntawv kev nyab xeeb

Cim GHS 07
GHS 07
Lus Cim Ceeb toom
Cov Lus Qhia Txog Hazard H302
Cov Lus Qhia Ua Ntej P301 + P312 + P330
Cov cuab yeej tiv thaiv tus kheej plua plav daim npog qhov ncauj hom N95 (US); Eyeshields; hnab looj tes
Hazard Codes Xn: Ua phem;
Risk kab lus R22
Cov lus nyab xeeb S22-S24/25
RIDADR 1544 ib
WGK Germany 3
RTECS VB2450000
Ntim Group III
Hazard Class 6.1 (b)
HS Code 293349090 ib

 Precursor & DownStream

Precursor 0
DownStream 1

 Kev lis kev cai

HS Code 293349090 ib
Cov ntsiab lus 2933499090. Lwm cov tshuaj uas muaj nyob rau hauv cov qauv quinoline los yog isoquinoline nplhaib-system (txawm los yog tsis hydrogenated), tsis ntxiv fused.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0%

 Cov ntawv108

Ntau cov ntawv

Itraconazole inhibits kev loj hlob ntawm glioblastoma los ntawm induction ntawm autophagy: kev koom tes ntawm txawv txav cov roj cholesterol.

Autophagy 10(7), 1241-55, (2014)

Glioblastoma yog ib qho mob hnyav tshaj plaws ntawm tib neeg cov qog nqaij hlav nrog cov tsos mob tsis zoo, thiab yog li ntawd qhov kev xav tau tseem ceeb muaj rau cov tswv yim kho tshiab rau kev tswj cov neeg mob glioblastoma.Itraconazol…

Regulators ntawm autophagosome tsim hauv Drosophila cov leeg.

PLoS Genet.11(2), e1005006, (2015)

Muab qhov sib txawv ntawm autophagy lub hom phiaj thiab kev tswj hwm, nws yog ib qho tseem ceeb rau kev ua tus cwj pwm autophagy hauv ntau hom cell thiab tej yam kev mob.Peb tau siv lub hauv paus myocyte cell kab lis kev cai los soj ntsuam lub luag haujlwm…

Ib txoj hauv kev sib xyaw ua ke los coj kev txhim kho cov hlau-chelateing inhibitors ntawm tus kab mob khaub thuas PA endonuclease.

Mol.Pharmacol.87(2), 323-37, (2015)

Tus kab mob npaws npaws PA endonuclease, uas cleaves capped cellular pre-mRNAs rau prime viral mRNA synthesis, yog lub hom phiaj zoo rau kev kho mob khaub thuas tshiab.Lub catalytic center ntawm t…

 Synonyms

TIAB SA 00069852
Acid phosphorique - N-(7-chloroquinoléin-4-yl)-N, N-diéthylpentane-1,4-diamine (2: 1)
Chloroquine phosphate
7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate
EINECS 200-055-2
N-(7-chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine bis (phosphate)
N4-(7-chloroquinolin-4-yl)-N1, N1-diethylpentane-1,4-diamine phosphate (1:2)
N-(7-Chloro-4-quinolinyl)-N, N-diethyl-1,4-pentanediamine phosphate (1:2)
N4-(7-Chloro-4-quinolyl)-N1, N1-diethyl-1,4-pentanediamine Diphosphate
Chloroquine diphosphate ntsev
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
Aralen phosphate
1,4-Pentanediamine, N-(7-chloro-4-quinolinyl)-N, N-diethyl-, phosphate (1:2)
1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-N1, N1-diethyl-, phosphate (1:2)
N-(7-Chloroquinolin-4-yl)-N, N-diethylpentane-1,4-diamine phosphate (1:2)
Chloroquine diphosphate
Imagon
Tresochin
Chloroquinediphosphate
Malaquin
Phosphorosäure-N-(7-chlorchinolin-4-yl)-N, N-diethylpentan-1,4-diamin (2: 1)

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    Vim li cas thiaj xaiv US?
    1. Xaiv cov khoom raw nruj me ntsis, peb cov khoom yog qhov siab tshaj plaws purity.
    2. Tus nqi tsim nyog thiab kev sib tw.Muab cov kev pabcuam zoo tshaj plaws thiab kev tshaj lij.
    3.Kev xa khoom sai ntawm cov qauv, cov qauv los ntawm Tshuag.Txhim khu kev xa khoom.
    4.Txhua qhov kev paub dhau los ntawm ntau lub thawv ntim khoom hauv Suav hiav txwv chaw nres nkoj.
    5. Qhov zoo tshaj plaws tom qab kev pab cuam tom qab xa khoom.
    6. Cov ntaub ntawv tshaj lij rau koj cov kev cai tshem tawm.

     

    1.Peb tuaj yeem lav qhov zoo?
    Ib txwm ua qauv ua ntej ua ntej ntau lawm;Ib txwm soj ntsuam zaum kawg ua ntej ua zaub mov xa tuaj.
    2.Vim li cas koj yuav tsum yuav los ntawm peb?
    (1) High purity zoo zoo nrog cov nqi sib tw zoo nkauj.(2) Lub peev xwm loj ntawm cov khoom lag luam ruaj khov.(3) Kev nyab xeeb thiab ceev khoom xa tuaj los ntawm hiav txwv / los ntawm huab cua.(4) Cov qauv txiav txim tau txais. (5) Zoo thiab nruj packing raws li customized.
    3.Koj tus MOQ yog dab tsi?Lub sijhawm xa khoom yog dab tsi?
    Feem ntau, peb cov MOQ yog 1kg.Tab sis nws tuaj yeem yog raws li koj qhov kev thov tiag tiag.Txhua qhov ntau yog OK.
    Feem ntau 2-3 hnub tom qab tau txais cov nyiaj them poob haujlwm (tshwj tsis yog suav hnub so)
    4.Puas muaj luv nqi?
    Tau kawg, peb yuav txiav txim siab luv nqi rau cov neeg yuav khoom thawj zaug, txawm tias muaj ntau ntau.
    5.Dab tsi cov nqe lus them nqi koj txais?peb xav lees txais kev hloov nyiaj hauv tuam txhab, Western Union lossis BTC.

    Sau koj cov lus ntawm no thiab xa tuaj rau peb